Spencer D Kwak

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Hyperoxia, during development in rats, results in hypoxic chemosensitivity ablation, carotid body hypoplasia, and reduced chemoafferents. We hypothesized that hyperoxia increases reactive oxygen species (ROS) in cell bodies of chemoafferents. Organotypic slices of petrosal-nodose ganglia from rats at day of life (DOL) 5-6 and 17-18 were exposed to 8%, 21%,(More)
Human neonates are uniquely susceptible to group B streptococcal (GBS) infections. We have shown that neonatal mixed mononuclear cells have a deficiency in the production of the T helper-1 (Th-1) cytokine, interferon gamma (IFN-gamma), and that incubation of neonatal neutrophils with recombinant IFN-gamma corrects these neutrophil defects. IL-12 and the(More)
Many patients treated for major depression in mental health and primary care settings fail to respond to adequate trials of available evidence-based treatments. Antidepressants, psychotherapy, and brain stimulation therapies have had some success, but many individuals do not respond to these treatments. Ketamine, a dissociative general anesthetic agent, is(More)
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