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Increased binding at 5-HT1A, 5-HT1B, and 5-HT2A receptors and 5-HT transporters in diet-induced obese rats
TLDR
Changes in the regional density of binding to 5-HT receptors and transporters and the levels of tryptophan hydroxylase, in rats with obesity induced by feeding a palatable high-energy diet for 7 weeks are demonstrated, consistent with reduced 5-hydroxytryptamine release and decreased activity of the 5- HT neurons. Expand
p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways
TLDR
The data uncover p53 as a keystone regulator of replication homeostasis within a DNA restart network and defines an unexpected role for p53-mediated suppression of replication genome instability. Expand
Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice.
TLDR
The results suggest that the protective effects of oleuropein against HFD-induced hepatic steatosis in mice appear to be associated with the Wnt10b- and FGFR1- mediated signaling cascades involved in hepatic lipogenesis, along with the TLR2- and TLR4-mediated signaling implicated in hepatosis. Expand
Selection of functional lactic acid bacteria as starter cultures for the fermentation of Korean leek (Allium tuberosum Rottler ex Sprengel.).
TLDR
The suitability of W. confusa LK4 as a potential starter culture for fermentation of leeks is suggested, which was mainly responsible for accelerated fermentation during the early period and showed correlation with anti-oxidant effects. Expand
Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet.
TLDR
The evidence obtained in this study suggests that carvacrol appears to inhibit visceral adipogenesis probably by suppressing bone morphogenic protein-, fibroblast growth factor 1- and galanin-mediated signaling, and it also attenuates the production of pro-inflammatory cytokines in visceral adipose tissues by inhibiting toll like receptor 2 (TLR2)- and TLR4- mediated signaling. Expand
Protective effects of Lactobacillus rhamnosus GG against dyslipidemia in high-fat diet-induced obese mice.
TLDR
A therapeutic potential of probiotics for ameliorating dyslipidemia and NAFLD is confirmed and shifts in the diversity of dominant gut bacteria were caused by HFD and restored by LGG treatment. Expand
The antipsychotic agent clozapine induces autophagy via the AMPK-ULK1-Beclin1 signaling pathway in the rat frontal cortex
TLDR
Results showed that clozapine activates autophagy through the AMPK–ULK1–Beclin1 signaling pathway in the frontal cortex of the rat and was mediated by AMPK signal pathway. Expand
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance
TLDR
Cumulatively, these studies demonstrate that SEMA3-mediated signaling drives the development of hypothalamic melanocortin circuits involved in energy homeostasis. Expand
A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene.
TLDR
ISL1 is established as a novel transcriptional regulator of LHX3 and a potential mechanism for regulation by PITX1 is described, suggesting models for analyses of the transcriptional pathways coordinating the expression of other LIM-HD genes and providing tools for the molecular analysis and genetic counseling of pediatric patients with combined pituitary hormone deficiency. Expand
Inhibitory Effect of the Hexane Extract of Saussurea lappa on the Growth of LNCaP Human Prostate Cancer Cells
TLDR
The present results indicate that HESL inhibits the growth of human prostate cancer cells by inducing apoptosis, which involves the activation of the caspase cascades. Expand
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