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Oncogene-induced senescence as an initial barrier in lymphoma development
Acute induction of oncogenic Ras provokes cellular senescence involving the retinoblastoma (Rb) pathway, but the tumour suppressive potential of senescence in vivo remains elusive. Recently,… Expand
A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
p53 and INK4a/ARF mutations promote tumorigenesis and drug resistance, in part, by disabling apoptosis. We show that primary murine lymphomas also respond to chemotherapy by engaging a senescence… Expand
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 trimethylation… Expand
The dynamic nature of senescence in cancer
Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous… Expand
Senescence-associated reprogramming promotes cancer stemness
Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the further expansion of (pre-)malignant cells. Key signalling components of the senescence machinery, such as… Expand
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Activated RAS/BRAF oncogenes induce cellular senescence as a tumor-suppressive barrier in early cancer development, at least in part, via an oncogene-evoked DNA damage response (DDR). In contrast,… Expand
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.
- C. Bouchard, Soyoung Lee, Viola Paulus-Hock, C. Loddenkemper, M. Eilers, C. Schmitt
- Medicine, Biology
- Genes & development
- 1 November 2007
FoxO transcription factors play critical roles in cell cycle control and cellular stress responses, and abrogation of FoxO function promotes focus formation by Myc in vitro. Here we show that stable… Expand
Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17–producing T-helper cell differentiation
- T. Nakahama, Hamza Hanieh, +9 authors T. Kishimoto
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 1 July 2013
Aryl hydrocarbon receptor (AHR) plays critical roles in various autoimmune diseases such as multiple sclerosis by controlling interleukin-17 (IL-17)–producing T-helper (TH17) and regulatory T cells.… Expand
Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
In malignancies, enhanced nuclear factor-κB (NF-κB) activity is largely viewed as an oncogenic property that also confers resistance to chemotherapy. Recently, NF-κB has been postulated to… Expand