Soyoung A. Oh

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Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has not been possible to distinguish iT reg from nT reg cells in(More)
The N-methyl-D-aspartate (NMDA) receptor plays a key role in synaptic plasticity and is thought to underlie memory, learning and development of the nervous system. The NMDA receptor is a ligand-gated ion channel complex that contains distinct recognition sites for endogenous and exogenous ligands, including glutamate, glycine, Mg2+, Zn2+ and noncompetitive(More)
Malignancy can be suppressed by the immune system in a process termed immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous cancers and the composition of participating cell types remains obscure. Here, we show that cell transformation triggers a tissue-resident lymphocyte response in oncogene-induced murine cancer models.(More)
The studies presented in this dissertation examine how the T cell receptor (TCR) specificity of CD4+CD25+ regulatory T (Treg) cells affects their function in a mouse model of autoimmune arthritis. TS1xHACII mice co-express CD4+ T cells that express the transgenic 6.5 TCR, which is specific for the S1 determinant of influenza virus PR8 hemagglutinin (HA),(More)
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