Sowmya Venkataramani

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In vitro neuronal networks with geometrically defined features are desirable for studying long-term electrical activity within the neuron assembly and for interfacing with external microelectronic circuits. In standard cultures, the random spatial distribution and overlap of neurites makes this aim difficult; hence, many recent efforts have been made on(More)
'Caged' compounds are biological molecules that are rendered inactive by a protecting (cage) group. Photocleaving of chemical bonds associated with the cage species with intense UV light results in the release of the active molecules. This technique, called flash photolysis, allows for real-time study of interacting biological molecules and typically(More)
We describe the use of compact green light-emitting diodes (LEDs) for fluorescence optical imaging and demonstrate this for dynamic recording from cultured neurons. The efficient gallium-nitride-based LEDs have individual element sizes comparable to typical biological cells and are operated in proximity illumination mode for individual neurons. As periodic(More)
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