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The RanGTPase activating protein RanGAP1 has essential functions in both nucleocytoplasmic transport and mitosis. In interphase, a significant fraction of vertebrate SUMO1-modified RanGAP1 forms a stable complex with the nucleoporin RanBP2/Nup358 at nuclear pore complexes. RanBP2 not only acts in the RanGTPase cycle but also is a SUMO1 E3 ligase. Here, we… (More)
SCIENCE sciencemag.org experience have been developed in studies involving research institutes in sending and receiving countries, e.g., the Mexican Migration Project (Princeton University), the “push and pull factors of international migration” project (a joint project of Eurostat and NIDI, Netherlands Interdisciplinary Demographic Institute), and the… (More)
A paper in the August 9 issue of Cell describes a novel role for the nucleoporin Npap60/Nup50 as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. These findings add a new dimension of complexity to the current understanding of protein transport pathways.