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Abbreviations RAGE Receptor for advanced glycation end products HMGB1 High mobility group box protein 1 sRAGE Soluble RAGE CML N(6)(carboxymethyl)lysine CEL N(6)(carboxyethyl)lysine MMPs Matrix metalloproteinases PTMs Post-translational modifications PPIs Protein-protein interactions BioPAX Biological PAthway eXchange
Chemokine (C-C motif) receptor 7 (CCR7), a class A subtype G-Protein Coupled Receptor (GPCR), is involved in the migration, activation and survival of multiple cell types including dendritic cells, T cells, eosinophils, B cells, endothelial cells and different cancer cells. Together, CCR7 signaling system has been implicated in diverse biological processes(More)
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