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Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease
Sustained neuroinflammation mediated by resident microglia is recognized as a key pathophysiological contributor to many neurodegenerative diseases, including Parkinson's disease (PD), but the keyExpand
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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease
The NLRP3 inflammasome signaling pathway is a major contributor to the neuroinflammatory process in the central nervous system. Oxidative stress and mitochondrial dysfunction are keyExpand
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Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.
AIMS Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive motor deficits and degeneration of dopaminergic neurons. Caused by a number of genetic and environmentalExpand
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Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes
HighlightsMn induces mitochondrial dysfunction in astrocytes.Mn exposure induces inflammatory response in astrocytes and exacerbates &agr;Synagg‐induced inflammatory response inExpand
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Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System
AbstractA growing body of evidence suggests that excessive microglial activation and pesticide exposure may be linked to the etiology of PD; however, the mechanisms involved remain elusive. EmergingExpand
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Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
Manganese exposure promotes α-synuclein propagation, neuroinflammation, and neurodegeneration. Manganese in Parkinson’s disease Manganese is an essential mineral, but chronic exposure to high amountsExpand
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Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
Fyn kinase mediates aggregated α-synuclein (αSyn) uptake as well as αSyn-mediated proinflammatory signaling in microglia, leading to NLRP3 inflammasome activation and neuroinflammation in Parkinson’sExpand
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Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy
Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase (SFK), and its immediateExpand
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Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults
HIGHLIGHTSBV2s have a high basal inflammatory state and are desensitized cells.MMCs are more suitable than BV2s for studying neuro‐inflammation and ‐toxicology.MMCs are more similar to neonatalExpand
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Pesticide-induced Mitochondrial Dysfunction Augments NLRP3 Inflammasome Signaling Pathway in Primary Microglia
Sustained neuroinflammation, oxidative stress and mitochondrial dysfunction are the key pathophysiological processes of many neurodegenerative diseases, including Parkinson's disease(PD). TheExpand
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