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Silk fibroin as biomaterial for bone tissue engineering.
TLDR
This review discusses and summarizes recent advancements in processing SF, focusing on different fabrication and functionalization methods and their application to grow bone tissue in vitro and in vivo, which provides an impressive toolbox and allows silk fibroin scaffolds to be tailored to specific applications. Expand
Bioprintable, cell-laden silk fibroin-gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs.
TLDR
3-D bioprinting offers a unique path forward in the direction of direct printing of spatially customized anatomical architecture in a patient-specific manner, delivering human nasal inferior turbinate tissue-derived mesenchymal progenitor cells encapsulated in silk fibroin-gelatin (SF-G) bioink. Expand
Three‐dimensional culture of melanoma cells profoundly affects gene expression profile: A high density oligonucleotide array study
TLDR
The data indicate that structural modifications of the architecture of tumor cell cultures result in a significant upregulation of the expression of a number of genes previously shown to play a role in melanoma progression and metastatic process. Expand
New dimensions in tumor immunology: what does 3D culture reveal?
TLDR
It is proposed that growth in 3D architectures might provide new insights into tumor immunology and could represent an integral missing component in pathophysiological tumor immune escape mechanisms. Expand
Comparative chondrogenesis of human cell sources in 3D scaffolds
TLDR
The results suggest that cell source differences are important to consider with regard to chondrogenic outcomes, and among the variables addressed here the human embryonic stem cells‐derived MSCs were the preferred cell source. Expand
Tissue engineering strategies to study cartilage development, degeneration and regeneration.
TLDR
Key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation and how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration are described. Expand
The role of 3D structure and protein conformation on the innate and adaptive immune responses to silk-based biomaterials.
TLDR
It is reported that untransformed CD14+ human monocytes respond to overnight exposure to silk fibroin-based biomaterials in tridimensional form by IL-1β and IL-6, but not IL-10 gene expression and protein production, while fibroIn based materials in bidimensional form are unable to stimulate monocyte responsiveness. Expand
Use of multicellular tumor spheroids to dissect endothelial cell–tumor cell interactions: A role for T‐cadherin in tumor angiogenesis
TLDR
Given an appropriate angiogenic tumor microenvironment, T‐cadherin upregulation on endothelial cells may potentiate intratumoral angiogenesis and lead to increased invasion and network formation within NA8‐MCTS. Expand
Silk‐Based Bioinks for 3D Bioprinting
TLDR
In this review, it is attempted to summarize the recent advancements made in the field of 3D bioprinting in context of two major sources of silk fibroin: silkworm silk and spider silk (native and recombinant). Expand
In vitro model of mesenchymal condensation during chondrogenic development.
TLDR
An in vitro biomaterials-based model to assess the interactions of matrix stiffness on chondrogensis is described herein, where by sensing subtle variation in morphology and stiffness of nanofibrous silk protein matrixes human mesenchymal stem cells migrated and assumed aggregated morphologies, mimicking early stage chondrogenesis. Expand
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