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Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction
- Mohammed M. Al Qaraghuli, Soumya Palliyil, Gillian Broadbent, D. Cullen, K. Charlton, A. Porter
- Medicine, Biology
- BMC Biotechnology
- 24 October 2015
BackgroundLow molecular weight haptens (<1000 Da) cannot be recognized by the immune system unless conjugated to larger carrier molecules. Antibodies to these exceptionally small antigens can still… Expand
High-Sensitivity Monoclonal Antibodies Specific for Homoserine Lactones Protect Mice from Lethal Pseudomonas aeruginosa Infections
- Soumya Palliyil, Christina Downham, I. Broadbent, K. Charlton, A. Porter
- Biology, Medicine
- Applied and Environmental Microbiology
- 1 November 2013
ABSTRACT A number of bacteria, including pathogens like Pseudomonas aeruginosa, utilize homoserine lactones (HSLs) as quorum sensing (QS) signaling compounds and engage in cell-to-cell communication… Expand
Novel immunotherapeutic approaches to the treatment of infections caused by Gram-negative bacteria.
The rise in infections caused by Gram-negative bacteria and the spread of resistance to conventional antibiotics provide significant challenges to the pharmaceutical industry. Monoclonal antibodies… Expand
Monoclonal Antibodies and Antibody Like Fragments Derived from Immunised Phage Display Libraries
Morbidity and mortality associated with infectious diseases are always on the rise, especially in poorer countries and in the aging population. The inevitable, but unpredictable emergence of new… Expand
Protective effect of quorum quenching monoclonal antibodies in lethal Pseudomonas infection
Quorum Quenching Monoclonal Antibodies for the Detection and Treatment of Gram-Negative Bacterial Infections
- Soumya Palliyil
- 4 May 2020
What are the trends in antimicrobial resistance patterns in bacteria isolated from companion animals in Scotland ?
Rapid diagnostics have potential to address the challenge of antimicrobial resistance (AMR) in humans and animals. However, successful development and application of novel diagnostic tools requires… Expand
Generation of High-Sensitivity Monoclonal Antibodies Specific for Homoserine Lactones.
- Soumya Palliyil
- Chemistry, Medicine
- Methods in molecular biology
A number of bacteria use a class of chemical compounds called acyl-homoserine lactones (AHLs) as quorum sensing (QS) signals to coordinate their behavior at the population level, including pathogens… Expand
Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
- Mohammad Arastoo, Richard A. Lofthouse, +4 authors Soumya Palliyil
- International journal of molecular sciences
- 1 November 2020
Despite continued efforts, there remain no disease-modifying drugs approved by the United States Food and Drug Administration (FDA) or European Medicines Agency (EMA) to combat the global epidemic of… Expand