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Recent studies revealed that the lymphotoxin/lymphotoxin beta receptor (LT)/LTbetaR system activates the noncanonical nuclear factor-kappaB (NF-kappaB) signaling pathway involving I kappa B kinase 1/I kappa B kinase alpha (IKK1/IKKalpha) and NF-kappaB-inducing kinase (NIK) to direct processing of the nfkappab2 protein p100 to yield RelB:p52 complexes.(More)
Inflammatory NF-kappaB/RelA activation is mediated by the three canonical inhibitors, IkappaBalpha, -beta, and -epsilon. We report here the characterization of a fourth inhibitor, nfkappab2/p100, that forms two distinct inhibitory complexes with RelA, one of which mediates developmental NF-kappaB activation. Our genetic evidence confirms that p100 is(More)
SUMMARY Inflammatory NF-kB/RelA activation is mediated by the three canonical inhibitors, IkBa,-b, and-3. We report here the characterization of a fourth inhibitor, nfkb2/p100, that forms two distinct inhibitory complexes with RelA, one of which mediates developmental NF-kB activation. Our genetic evidence confirms that p100 is required and sufficient as a(More)
The NFκB family of dimeric transcription factors regulate inflammatory and immune responses. While the dynamic control of NFκB dimer activity via the IκB-NFκB signalling module is well understood, there is little information on how specific dimer repertoires are generated from Rel family polypeptides. Here we report the iterative construction-guided by in(More)
Tissue microenvironment functions as an important determinant of the inflammatory response elicited by the resident cells. Yet, the underlying molecular mechanisms remain obscure. Our systems-level analyses identified a duration code that instructs stimulus specific crosstalk between TLR4-activated canonical NF-κB pathway and lymphotoxin-β receptor (LTβR)(More)
Using Komar's definition, we give expressions for the mass and angular momentum of a rotating acoustic black hole. We show that the mass and angular momentum so defined, obey the equilibrium version of the first law of Black Hole thermodynamics. We also show that when a phonon passes by a vortex with a sink, its trajectory is bent. The angle of bending of(More)
(received ; accepted) PACS. 47.55Mh – Flows through porous media. PACS. 47.55Kf – Multi-phase and particle-laden flows. Abstract. – We investigate the burst dynamics during drainage going from low to high injection rate at various fluid viscosities. The bursts are identified as pressure drops in the pressure signal across the system. We find that the(More)
Environmental drug resistance constitutes a serious impediment for therapeutic intervention in multiple myeloma. Tumor-promoting cytokines, such as tumor necrosis factor (TNF), induce nuclear factor-κB (NFκB)- driven expression of pro-survival factors, which confer resistance in myeloma cells to apoptotic insults from TNF-related apoptosis-inducing ligand(More)