Sougata Sinha Ray

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BACKGROUND Malaria caused by the parasite Plasmodium falciparum is a major public health concern. The parasite lacks a functional tricarboxylic acid cycle, making glycolysis its sole energy source. Although parasite enzymes have been considered as potential antimalarial drug targets, little is known about their structural biology. Here we report the crystal(More)
The conformational stability of Plasmodium falciparum triosephosphate isomerase (TIMWT) enzyme has been investigated in urea and guanidinium chloride (GdmCl) solutions using circular dichroism, fluorescence, and size-exclusion chromatography. The dimeric enzyme is remarkably stable in urea solutions. It retains considerable secondary, tertiary, and(More)
Cropping system level study is not only useful to understand to overall sustainability of agricultural system, but also it helps in generating many important parameters which are useful in climate change impact assessment. Considering its importance, Space Applications Centre, took up a project for mapping and characterizing major cropping systems of(More)
Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the generation of ATP. Interestingly, this molecule as well as several antigenic proteins act as bio-markers for the detection of leprosy. One such bio-marker is(More)
The nitric oxide synthase of Drosophila melanogaster (dNOS) participates in essential developmental and behavioral aspects of the fruit fly, but little is known about dNOS catalysis and regulation. To address this, we expressed a construct comprising the dNOS reductase domain and its adjacent calmodulin (CaM) binding site (dNOSr) and characterized the(More)
  • K N Chaudhari, M P Oza, S S Ray
  • 2009
The regional models of yield response to temperature (minimum, maximum and its diurnal range) and precipitation developed for meteorological (met) subdivisions of India were used to study the impact of future climate change on major food crops viz. wheat, rice, potato and rapeseed-mustard. The area weighted averages of district-wise crop yield data were(More)
  • S S Ray, S Bandyopadhyay, P Mitra, S K Pal
  • 2000
Different bioinformatics tasks like gene sequence analysis, gene finding, protein structure prediction and analysis, gene expression with microarray analysis and gene regulatory network analysis are described along with some classical approaches. The relevance of intelligent systems and neural networks to these problems is mentioned. Different neural(More)
Mycobacterium leprae HSP18, a major immunodominant antigen of M. leprae pathogen, is a small heat shock protein. Previously, we reported that HSP18 is a molecular chaperone that prevents aggregation of different chemically and thermally stressed client proteins and assists refolding of denatured enzyme at normal temperature. We also demonstrated that it can(More)
  • P Swami, T Gandhi, S S Ray, S Anand
  • 2012
— This paper illustrates a novel topology for the conditioning of electro-oculogram signals. The system is composed of a second order amplification chain and assures stability, speed and accuracy. The proposed configuration has been developed in order t o make signal acquisition of biological signals such as electro-oculogram simpler and robust with low(More)
Global climate change can affect yields of agricultural crops are likely to be affected due to rise in CO 2 and temperature, apart from other factors. In this context, the present study aimed at to assess the effects of elevated ambient CO 2 concentration, maximum and minimum temperatures alone and in combinations on crop productivity of three major(More)