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Phytol directly activates peroxisome proliferator-activated receptor α (PPARα) and regulates gene expression involved in lipid metabolism in PPARα-expressing HepG2 hepatocytes
Abstract The peroxisome proliferator-activated receptor (PPAR) is one of the indispensable transcription factors for regulating lipid metabolism in various tissues. In our screening for naturalExpand
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Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice.
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates the expression of the genes involved in fatty acid oxidation. PPARα activators induceExpand
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Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist
The cholesterol biosynthetic pathway produces not only sterols but also non-sterol mevalonate metabolites involved in isoprenoid synthesis. Mevalonate metabolites affect transcriptional andExpand
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  • Open Access
Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.
The peroxisome proliferator-activated receptor (PPAR) is one of the indispensable transcription factors for regulating lipid metabolism in various tissues. In our screening for natural compounds thatExpand
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Freezing-Induced Mechanoluminescence of Polymer Gels
Mechanochromism can be triggered by different mechanical stimuli, such as tension, compression, shearing, and sonication. Freezing a polymer gel also induces mechanical stress on the polymer network.Expand
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Introducing static cross-linking points into dynamic covalent polymer gels that display freezing-induced mechanofluorescence: enhanced force transmission efficiency and stability
Freezing polymer gels that are cross-linked by tetraarylsuccinonitrile (TASN) moieties, which can generate pink and fluorescent yellow radicals in response to mechanical stress, inducesExpand
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How Valuable is Prime Minister's Dissolution Option?: Black-Scholes Approach to Parliamentary Dissolution
When does the prime minister call election? This paper attempts to solve the puzzle by utilizing financial option pricing model developed in the field of financial economics. We construct anExpand
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Identification and visualization of pitching motion using deep learning
Internal Structure of Hyaluronic Acid Hydrogels Controlled by Iron(III) Ion–Catechol Complexation
This study explores the internal structure of catechol-functionalized hyaluronic acid (HA–CA) hydrogels with different types of Fe3+-induced cross-linking. We previously reported HA–CA hydrogelsExpand
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