Sosuke Hanai

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This paper reviews studies in vivo and in vitro on the reproductive and developmental toxicity of manufactured nanomaterials including metallic and metal oxide-based particles, fullerenes (C(60)), carbon black (CB), and luminescent particles. Studies in vivo showed increased allergic susceptibility in offspring of mouse dams intranasally insufflated with(More)
An electrochemical surface shear stress measurement was applied to a model of unilateral arterial stenosis. The unilateral stenosis model was made up of a removable stenosis plug, in an electrochemical shear stress measurement test section with 100 cathodes. Three dimensional wall shear stress distribution was measured under steady flow field. At a(More)
An electrochemical surface shear stress measurement was applied to a model of very thin unilateral arterial stenosis (height of 1/8 of the model pipe diameter with very smooth surface). Three dimensional wall shear stress distribution was measured under steady flow field from a relatively low Reynolds number, Re = 270, to a high Reynolds number, Re = 1200.(More)
A vasomotion activity in the mesentery of anesthetized rabbits were studied by simultaneous measurements of inside diameters at multiple sites in arterioles, precapillaries and their bifurcations. A frame-by-frame diameter determination technique was used with a microcomputer-assisted laser video disk recorder and video-image analysis system. Simultaneous(More)
This study assessed the health risks via inhalation and derived the occupational exposure limit (OEL) for the carbon nanotube (CNT) group rather than individual CNT material. We devised two methods: the integration of the intratracheal instillation (IT) data with the inhalation (IH) data, and the "biaxial approach." A four-week IH test and IT test were(More)
Turbulent velocity fluctuations were measured and analyzed in the canine ascending aorta using a hot-film anemometer. Blood flow rate and temperature were stabilized using a special bypass technique. Blood pressure was elevated by Methoxamine infusion. Turbulence components were extracted from measured data using an ensemble averaging technique. Turbulence(More)
An application of the computational fluid mechanical method to the air flow in a two-dimensional model of an infant incubator was described. The air flow in a numerical model was simulated and the Navier-Stokes equations were directly solved using a finite-volume method incorporating a body-fitted coordinate system on a minisupercomputer. The model was(More)
Arterioles in various vascular beds have been often observed to have nonuniform diameters along the vessel axis. The effect of nonuniformity of arteriolar diameter on vascular resistance was investigated using a theoretical model of blood flow in arterioles. Viscous flow of a Newtonian fluid in tubes with periodically changing diameters along the tube axis(More)
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