Sorena Kiani-Alikhan

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The chronic fatigue syndrome (CFS), as defined by recent criteria, is a heterogeneous disorder with a common set of symptoms that often either follows a viral infection or a period of stress. Despite many years of intense investigation there is little consensus on the presence, nature and degree of immune dysfunction in this condition. However, slightly(More)
We describe a family with the rare mutation R11X that leads to a truncated CD40 ligand (CD40L) missing the intracellular domain. The index case had detectable CD40L expression and presented at the age of 41 years with cerebral toxoplasmosis. A brother and two nephews were also identified as having the same mutation but exhibited milder and variable(More)
To the Editor, In the majority of primary antibody deficiency (PAD) patients receiving IgG replacement therapy (IgGRT), the risk of serious infections is reduced; however, a significant proportion continue to have upper and lower respiratory tract infections [1]. It is thought that IgA and IgM are physiologically important for protecting the mucosal(More)
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