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Several previous reports suggest that thrombospondin (TSP-1) may be a mediator of the antiangiogenic effects of low-dose metronomic cyclophosphamide-based chemotherapy (MC). We conducted a randomized phase II trial evaluating megestrol acetate (n = 44) versus MC (n = 44) in patients having exhausted all standard treatments. We measured the TSP-1 levels at(More)
The sensitivity of CSF cytology, the standard method for diagnosis of leptomeningeal metastases (LM), is low. Serum cancer antigen 15-3 (CA 15-3) is frequently used for the monitoring of patients with breast cancer (BC) and is a laboratory test available in most centers. The aim of the current study was to determine the feasibility of measuring CSF CA 15-3(More)
2075 Background: An increased incidence of leptomeningeal metastases (LM) is reported in breast cancer (BC), which is the predominant etiology of LM in solid tumors Our aim was to assess the significance of intra-CSF CA 15-3 measure in the early diagnosis of BC LM. METHODS Serum and CSF levels of CA 15-3 and albumine were evaluated in 4 groups of 20(More)
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