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GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1α (HIF-1α) pathways.

• Natalie Burrows, Muhammad Naveed Babur, +5 authors Kaye J. Williams
• The Journal of clinical endocrinology and…
• 2011

CONTEXT Phosphoinositide 3-kinase (PI3K) regulates the transcription factor hypoxia-inducible factor-1 (HIF-1) in thyroid carcinoma cells. Both pathways are associated with aggressive phenotype in… (More)

The kinetics and mechanism of cobalamin-dependent methyl and ethyl transfer to mercuric ion.

• Robert Desimone, M W Penley, +6 authors R. J. Williams
• Biochimica et biophysica acta
• 1973

Age differences in children's ability to model motor behavior.

• J. R. Thomas, Christy M. Pierce, Sophie Ridsdale
• Research quarterly
• 1977

Methyl transfer from methyl vitamin B 12 .

• Gironde Agnès, H A Hill, Jesse M. Pratt, Sophie Ridsdale, Francis Kennedy, R. J. Williams
• Biochimica et biophysica acta
• 1971

Acid denaturation studies on a cobalt(3) protoporphyrin-globin complex.

• Sophie Ridsdale, James C. Cassatt, Joerg Steinhardt
• The Journal of biological chemistry
• 1973

A cobalt (III)-protoporphyrin IX complex of horse globin (cobaltiglobin) has been prepared and its stability toward acid denaturation determined. Unlike iron(II1) protoporphyrin, which combines with.… (More)

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