Sophie Pelloux

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8-oxoguanine DNA glycosylase and Kin17 are proteins widely distributed and phylogenetically conserved in the CNS. 8-oxoguanine DNA glycosylase is a DNA repair enzyme that excises 7,8-dihydro-8-oxoguanine present in DNA damaged by oxidative stress. Kin17 protein is involved in DNA repair and illegitimate recombination in eukaryotic cells. The present study(More)
OBJECTIVE To evaluate the cytotoxicity of iron nanoparticles on cardiac cells and to determine whether they can modulate the biological activity of 7-ketocholesterol (7KC) involved in the development of cardiovascular diseases. Nanoparticles of iron labeled with Texas Red are introduced in cultures of nonbeating mouse cardiac cells (HL1-NB) with or without(More)
We studied in confocal microscopy non-beating cells from the HL-1 cardiac cell line. Using a fluorescent dye, mitochondria appeared as a dense tubular network, in permanent fusion, fission and displacement. To quantify these movements in response to pharmacological stimuli, we needed a method only based on their position. Time-lapse recording was performed(More)
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