Sophie Lee

Learn More
Increased aortic stiffness is a biomarker for subsequent adverse cardiovascular events. We have previously reported that vascular smooth muscle Src-dependent cytoskeletal remodelling, which contributes to aortic plasticity, is impaired with ageing. Here, we use a multi-scale approach to determine the molecular mechanisms behind defective Src-dependent(More)
To guide the use of human mesenchymal stem cells (MSCs) toward clinical applications, identifying pluripotent-like-markers for selecting MSCs that retain potent self-renewal-ability should be addressed. Here, an insulin-like growth factor 1 receptor (IGF1R)-expressing sub-population in human dental pulp MSCs (hDSCs), displayed multipotent properties. IGF1R(More)
2003 ii We have read this dissertation entitled " Mechanisms of Polyglutamine Expanded Huntingtin Induced Toxicity " by Haibing Jiang, and recommend that it be accepted towards the partial fulfillment of the requirement for the degree of Doctor of Philosophy. Huntington's Disease (HD) belongs to the CAG repeat family of neurodegenerative diseases and is(More)
  • 1