Sophie Grabar

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BACKGROUND Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load. METHODS AND FINDINGS Using data from the Collaboration of Observational HIV Epidemiological Research Europe (2010(More)
BACKGROUND Patterns of cause-specific mortality in individuals infected with human immunodeficiency virus type 1 (HIV-1) are changing dramatically in the era of antiretroviral therapy (ART). METHODS Sixteen cohorts from Europe and North America contributed data on adult patients followed from the start of ART. Procedures for coding causes of death were(More)
BACKGROUND Concomitant syphilis and human immunodeficiency virus (HIV) infection is increasingly frequent in industrialized countries. METHODS From a large hospital cohort of HIV-infected patients followed up in the Paris area between 1998 and 2006, we examined the effect of early syphilis on plasma HIV-1 RNA levels and CD4 cell counts. We compared 282(More)
OBJECTIVE To increase equitable access to life insurance for HIV-positive individuals by identifying subgroups with lower relative mortality. DESIGN Collaborative analysis of cohort studies. METHODS We estimated relative mortality from 6 months after starting antiretroviral therapy (ART), compared with the insured population in each country, among adult(More)
OBJECTIVE The Aide dans la Maladie d'Alzheimer (AIDMA) study was conducted to determine whether a psycho-educational programme (PEP) for primary caregivers in addition to standard anti-dementia drugs for patients improves caregivers' psychological condition and patients' activities of daily life. METHOD Multicentre randomised controlled intervention(More)
OBJECTIVES Surgery duration is a source of preoperative anxiety for patients undergoing cataract surgery. To better inform patients, we evaluated the agreement between objective and patient-perceived surgery durations. DESIGN Case series. SETTING Public teaching university hospital (Paris, France). PARTICIPANTS During the study period, 368 cataract(More)
BACKGROUND There is limited knowledge of the MRI pattern of the development of fetal olfactory bulbs and sulci. OBJECTIVE To describe the MRI appearance of olfactory bulbs and sulci in normal in vivo fetuses according to gestational age. MATERIALS AND METHODS Olfactory bulbs and sulci were retrospectively assessed on brain MRI examinations of 88 normal(More)
BACKGROUND Pulp necrosis is one of the main complications of dental trauma. When it happens on an immature tooth, pulp necrosis implies a lack of root maturation and apical closure. A therapy called apexification is required to induce the formation of a calcified apical barrier allowing a permanent and hermetic root filling. The aim of this prospective(More)
OBJECTIVES To estimate mortality rates and prognostic factors in HIV-positive patients who started combination antiretroviral therapy between 1996-1999 and survived for more than ten years. METHODS We used data from 18 European and North American HIV cohort studies contributing to the Antiretroviral Therapy Cohort Collaboration. We followed up patients(More)
INTRODUCTION The aim of this study was to assess the efficacy and safety of tumor necrosis factor (TNF)-α inhibition with infliximab (IFX) in treating recurrent and disabling chronic sciatica pain associated with post-operative peridural lumbar fibrosis. METHOD A double-blind, placebo-controlled study randomized 35 patients presenting with sciatica pain(More)