Sophie Franceschi-Messant

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Chloroaluminum phthalocyanine (ClAlPc) is a promising sensitizer molecule for photodynamic therapy, but its hydrophobicity makes it difficult to formulate. In this study, we have efficiently encapsulated ClAlPc into gelled soybean oil particles dispersed in water. 12-Hydroxystearic acid (HSA) and polyethyleneimine (PEI) were the gelling and stabilizing(More)
Based on the organogel concept, in which an oil is trapped in a network of low-molecular-mass organic gelator fibres creating a gel, a formulation of gelled soya bean oil nanoparticles was evaluated for its capacity to form biocompatible hydrophobic reservoirs. The aqueous dispersions of nanoparticles were prepared by hot emulsification (T° > Tgel) and(More)
The rheological properties of a new type of colloidal dispersion based on nanoparticles of gelled oil have been characterized. The nanoparticles (mean diameter approximately 250 nm) were viscoelastic droplets of dicaprylyl ether gelled by 12-hydroxystearic acid (HSA) and were stabilized in aqueous solutions by cetyltrimethylammonium bromide. The effects of(More)
We report on a new approach for creating water-soluble functionalized vesicles employing N-alkyl-3-boronopyridinium triflates (alkyl = Me, C12H25, C16H33) as sensors for monosaccharides. The nanoaggregate properties were studied by means of DLS, TEM, high-resolution (1)H NMR, and the solvatochromic dyes Reichardt's betaine and Methyl Orange. The vesicles(More)
Rheological Study: The rheological properties of the organogels were studied by an advanced rheological expansion system (Advanced Rheometer AR-1000, TA Instruments, USA). The gel was first dissolved in an oven at 100°C and then 1 mL of this solution was dropped between the two parallel plates of the AR-1000. The upper plate (cone diameter = 60 mm, cone(More)
A new method based on the use of porous organogel materials in combination with liquid chromatography-tandem mass spectrometry (LC-MS-MS) was assessed for the quantification of trace contaminants in complex matrices. As a demonstration of the use of these new materials, the contaminant chosen as a model was bisphenol A (BPA) and its extraction was(More)
A new family of polymerizable surfactants was synthesized starting from a 1:1 mixture of alkylcarboxylic acids (C(10) to C(16)) and norbornene methyleneamine. The ion-paired surfactants exhibited cloud temperatures, surface activity, and critical aggregation concentrations that differed according to the chain length, with a variation indicating a strongly(More)
The natural packaging of DNA in the cell by histones provides a particular environment affecting its sensitivity to oxidative damage. In this work, we used the complexation of DNA by cationic surfactants to modulate the conformation, the dynamics, and the environment of the double helix. Photo-oxidative damage initiated by benzophenone as the(More)
Various porous scaffolds utilizing an organogel were prepared by particulate-leaching method. The porous organogels were made of biodegradable, non-toxic ingredients like soybean oil or caprylic/capric triglyceride as the organic liquids and 12-hydroxystearic acid as the gelator. The scaffolds possessed an effective porosity of 56-65%, and good pore(More)
Complexes of DNA with various cationic vectors have been largely used for nonviral transfection, and yet the photochemical stability of DNA in such complexes has never been considered. We studied, for the first time, the influence of DNA complexation by a cationic lipid and polymers on the amount of damage induced by benzophenone photosensitization. The(More)