Sophie Demont-Guignard

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OBJECTIVE In partial epilepsies, interictal epileptic spikes (IESs) and fast ripples (FRs) represent clinically relevant biomarkers characteristic of epileptogenic networks. However, their specific significance and the pathophysiological changes leading to either FRs or IESs remain elusive. The objective of this study was to analyze the conditions in which(More)
The pathophysiological interpretation of EEG signals recorded with depth electrodes [i.e., local field potentials (LFPs)] during interictal (between seizures) or ictal (during seizures) periods is fundamental in the presurgical evaluation of patients with drug-resistant epilepsy. Our objective was to explain specific shape features of interictal spikes in(More)
Epilepsy is a neurological disorder characterized by recurrent seizures which affects about 1% people worldwide. During the past decades, some mechanisms involved in ictogenesis (generation of seizures) have been identified and, to some extent, partially understood. However, regarding epileptogenesis (process by which a neuronal system becomes epileptic),(More)
This paper deals with the interpretation of the macroscopic features of epileptic spikes recorded in human hippocampus based on a neural network model of the CA1 subfield. The network consists of principal cells (pyramidal neurons) and local interneurons and uses GABAergic and glutamatergic synapses. For pyramidal cells, this paper introduces a novel(More)
Oxygen glucose deprivation (OGD) leads to rapid suppression of synaptic transmission. Here we describe an emergence of rhythmic activity at 8 to 20 Hz in the CA3 subfield of hippocampal slice cultures occurring for a few minutes prior to the OGD-induced cessation of evoked responses. These oscillations, dominated by inhibitory events, represent network(More)
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