Sophie Coutant

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Whole exome sequencing (WES) has become the strategy of choice to identify a coding allelic variant for a rare human monogenic disorder. This approach is a revolution in medical genetics history, impacting both fundamental research, and diagnostic methods leading to personalized medicine. A plethora of efficient algorithms has been developed to ensure the(More)
  • Daniel Stockholm, Frédérique Edom-Vovard, Sophie Coutant, Peggy Sanatine, Yoshiaki Yamagata, Guillaume Corre +3 others
  • 2010
BACKGROUND In culture, isogenic mammalian cells typically display enduring phenotypic heterogeneity that arises from fluctuations of gene expression and other intracellular processes. This diversity is not just simple noise but has biological relevance by generating plasticity. Noise driven plasticity was suggested to be a stem cell-specific feature. (More)
  • Isabelle Tournier, Régine Marlin, Kelly Walton, Françoise Charbonnier, Sophie Coutant, Jean-Christophe Théry +15 others
  • 2014
To identify novel genetic bases of early-onset epithelial ovarian tumors, we used the trio exome sequencing strategy in a patient without familial history of cancer who presented metastatic serous ovarian adenocarcinomas at 21 years of age. We identified a single de novo mutation (c.1157A>G/p.Asn386Ser) within the INHBA gene encoding the βA-subunit of(More)
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