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Post-transcriptional regulatory mechanisms are widely used to control gene expression programs of tissue development and physiology. Controlled 3' poly(A) tail-length changes of mRNAs provide a mechanistic basis of such regulation, affecting mRNA stability and translational competence. Deadenylases are a conserved class of enzymes that facilitate poly(A)(More)
To avoid organ dysfunction as a consequence of tissue diminution or tumorous growth, a tight balance between cell proliferation and differentiation is maintained in metazoans. However, cell-intrinsic gene expression mechanisms controlling adult tissue homeostasis remain poorly understood. By focusing on the adult Caenorhabditis elegans reproductive tissue,(More)
During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous recombination (HR)-mediated repair of programmed DNA double strand breaks (DSBs). As more DSBs are induced than COs, mechanisms are required to establish a regulated number of COs and to repair remaining(More)
The correct Acknowledgments are: We are thankful to Jane Wright and Rafal Ciosk (FMI) for generously providing the transgenic lines; and Eli Knust for critically reading the manuscript; Mark Schmid and Agata Rybarska for initial strain analysis; Carrie Cowan for the cye-1(RNAi) construct; the MPI-CBG antibody and protein expression facilities for antisera(More)
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