Sophia Millonigg

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Post-transcriptional regulatory mechanisms are widely used to control gene expression programs of tissue development and physiology. Controlled 3' poly(A) tail-length changes of mRNAs provide a mechanistic basis of such regulation, affecting mRNA stability and translational competence. Deadenylases are a conserved class of enzymes that facilitate poly(A)(More)
To avoid organ dysfunction as a consequence of tissue diminution or tumorous growth, a tight balance between cell proliferation and differentiation is maintained in metazoans. However, cell-intrinsic gene expression mechanisms controlling adult tissue homeostasis remain poorly understood. By focusing on the adult Caenorhabditis elegans reproductive tissue,(More)
During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous recombination (HR)-mediated repair of programmed DNA double strand breaks (DSBs). As more DSBs are induced than COs, mechanisms are required to establish a regulated number of COs and to repair remaining(More)
Jakub Novak should be included in the author byline instead of the Acknowledgments. He should be the fourth author, and his affiliation is: Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany The correct citation is: Millonigg S, Minasaki R, Nousch M, Novak J, Eckmann CR (2014) GLD-4-Mediated Translational Activation(More)
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