Learn More
Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in(More)
We present the DNA sequence and a functional dissection of the 1483 residue yeast activator HAP1. Salient results are, first, a single DNA binding domain (1-148) specifies binding to the two target sites of different sequence, UAS1 and CYC7. This domain contains a cysteine-rich zinc finger, and mutation of either of two cysteines abolishes binding to both(More)
The signatures of the Dissertation Defense Committee signify completion and approval as to style and content of the Dissertation The signature of the Dean of the Graduate School of Biomedical Sciences signifies that the student has met all graduation requirements of the school. iii Acknowledgements First and foremost, I would like to thank my mentor,(More)
  • 1