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Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation
Astrocytes are thought to have important roles after brain injury, but their behavior has largely been inferred from postmortem analysis. To examine the mechanisms that recruit astrocytes to sites ofExpand
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Genetic Deletion of Cdc42 Reveals a Crucial Role for Astrocyte Recruitment to the Injury Site In Vitro and In Vivo
It is generally suggested that astrocytes play important restorative functions after brain injury, yet little is known regarding their recruitment to sites of injury, despite numerous in vitroExpand
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Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface
Blood proteins at the neurovascular unit (NVU) are emerging as important molecular determinants of communication between the brain and the immune system. Over the past two decades, roles for theExpand
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Superficial Nephrons in BALB/c and C57BL/6 Mice Facilitate In Vivo Multiphoton Microscopy of the Kidney
Multiphoton microscopy (MPM) offers a unique approach for addressing both the function and structure of an organ in near-real time in the live animal. The method however is limited by theExpand
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Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) andExpand
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Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
Oxidative stress is a central part of innate immune-induced neurodegeneration. However, the transcriptomic landscape of central nervous system (CNS) innate immune cells contributing to oxidativeExpand
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Heterogeneity in astrocyte responses after acute injury in vitro and in vivo
Astrocytes present a major population of glial cells in the adult mammalian brain. The heterogeneity of astrocytes in different regions of the healthy central nervous system (CNS) and theirExpand
Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Finding the 'ubiquitous' threads in infection and autoimmune neuroinflammation
The deubiquitinase USP15 acts with the ubiquitin ligase TRIM25 to activate a type I interferon response and exacerbate microbial and autoimmune neuroinflammation.
3D profiling of amyloid plaque-associated microglia and neuronal damage on confocal fluorescence images to aid drug discovery in Alzheimer's disease
Alzheimer’s disease (AD), one of the most common cause of dementia, is a complex neurodegenerative disease marked by amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles. Genome-wideExpand