Soon-Jae Hwang

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Fibrous dysplasia is a bone disorder of unknown origin characterized by slow, progressive replacement of bone by abnormal proliferative isomorphic fibrous tissue. The disease was first described by McCune and Bruch in 1937. Craniofacial involvement is found in only 10% of cases of the monostotic variety, while temporal bone involvement is rare. We report(More)
OBJECTIVE Otitis media (OM) is the most common disease in preschool age children related to passive cigarette smoking as risk factor. In this study, we investigate whether the cigarette smoking can induce the inflammation in human middle ear epithelial cell, and cigarette smoke-induced inflammation can increase the expression of MUC5AC gene and protein that(More)
Secretory leukocyte protease inhibitor (SLPI) is a cationic protein and a member of the innate immunity-associated protein family. The main function of SLPI is to protect local tissue against the detrimental consequences of inflammation. We undertook this study to investigate the expression of SLPI in human middle ear cholesteatoma tissue as compared with(More)
CONCLUSIONS The results suggest that the anti-inflammatory effect of caffeic acid phenethyl ester (CAPE) is due to its inhibition of tumor necrosis factor (TNF)-alpha expression and interleukin (IL)-8 production. The anti-inflammatory effect of CAPE is possibly through the inhibition of nuclear factor (NF)-kappaB via the suppression of(More)
CONCLUSION Increased psoriasin in cholesteatoma epithelium may play a role in epithelial inflammatory response and differentiation. OBJECTIVES Cholesteatoma is characterized by excessive keratinocyte differentiation leading to inflammation, granulation tissue, and osteolytic activity. Moreover, psoriasin may act as an antimicrobial peptide, stimulate(More)
Castleman’s disease is an uncommon benign disease that causes progressive lymph node enlargement. We report 12 cases of Castleman’s disease in the head and neck region in a retrospective review of the medical records of all patients with the pathological diagnosis of Castleman’s disease during the period of 1993 through 2002. In the 12 patients, the neck(More)
OBJECTIVE The epithelial cells of the middle ear and Eustachian tube must maintain an adequate mucosal defense system against various antigenic stimuli. Since toll-like receptors (TLRs) are known to play a critical role in mucosal defense, we investigated their expression in the mucosa of the tubotympanum, nasopharynx, and oral cavity of the rat. METHOD(More)
We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse(More)
OBJECTIVE To assess the efficacy of treatment of a ranula in children by intralesional injection of OK-432. STUDY DESIGN Retrospective analysis of 13 cases. METHODS Review of medical records of pediatric patients with ranula treated by OK-432 sclerotherapy from 2002 through 2005. RESULTS Among 13 cases, 9 were completely regressed by injection therapy(More)
OBJECTIVES Cholesteatoma is characterized by an excessive proliferation and differentiation of keratinocytes with a progressive accumulation of keratin debris. Caspase-14 is a novel regulator of keratinocyte terminal differentiation. The purpose of this study was to investigate the expression patterns and localizations of caspase- 14 in cholesteatoma and in(More)