Soomi Kim

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Bloom's syndrome (BS), a disorder associated with genomic instability and cancer predisposition, results from defects in the Bloom's helicase (BLM) protein. In BS cells, chromosomal abnormalities such as sister chromatid exchanges occur at highly elevated rates. Using Xenopus egg extracts, we have studied Xenopus BLM (Xblm) during both unperturbed and(More)
BACKGROUND In the budding yeast, Saccharomyces cerevisiae, each DNA replication origin is associated with an autonomously replicating sequence (ARS) element. Each element contains several modules, including an essential close match to the 11 base-pair (bp) ARS consensus sequence (ACS) and two or three short (< 20 bp) stimulatory motifs, within a stretch of(More)
BACKGROUND Some origins in eukaryotic chromosomes fire more frequently than others. In the fission yeast, Schizosaccharomyces pombe, the relative firing frequencies of the three origins clustered 4-8 kbp upstream of the ura4 gene are controlled by a replication enhancer - an element that stimulates nearby origins in a relatively position-and(More)
Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA damage-inducing therapeutics. Here we identify an HR defect (HRD) gene signature that can be used to functionally assess HR repair status without interrogating individual genetic alterations in cells. By using this HRD gene signature as(More)
In the diverse research on Multi Commercial Complexes, rather than a technical and statistical approach, it is now time to focus on the quality of urban sustainability based on the daily experience of urban residents. Therefore, this research proposes a mechanism for making a sophisticated adjustment to the " Ground " , defined as the empty space of a(More)
Cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs. Recently CDs have been foused as therapeutics for neurodegenerative diseases. However, some CDs are toxic when administered parenterally. In this study, we investigated the effects of MβCD, a methylated form of β-CD, on endothelial cells using ECV 304 cells, a human endothelial cell(More)
Endogenous opioid peptides, found in the central and peripheral nervous systems, perform neuromodulatory roles, and display a wide range of functional and pharmacological properties in vitro and in vivo. In this study, we investigated the effects of prodynorphin gene products on intracellular signaling events and cell survival in rat pheochromocytoma PC12(More)
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