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Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model.
Transforming Growth Factor-β Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail.
Ectopic expression of Snail restored liver tumorigenesis suppressed by disruption of TGF-β signaling, and gene expression levels in human hepatocellular carcinoma samples deposited in The Cancer Genome Atlas showed Snail expression correlated with T GF-β activation.
Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats
It is concluded that MLB has potent antifibrotic effect in TAA-treated cirrhotic rats, and inhibits fibrogenic responses in HSCs, and suggests that MLB have potential as a novel therapy for hepatic fibrosis.
Investigation of Oncogenic Cooperation in Simple Liver-Specific Transgenic Mouse Models Using Noninvasive In Vivo Imaging
A simple methodology by which oncogenic cooperation between cancer-related genes can be efficiently investigated in the liver is reported by which firefly luciferase was co-expressed with the oncogenes as a reporter, allowing tumor growth in the Liver to be monitored over time without an invasive procedure.
Identification of proteins indicating radiation-induced hepatic toxicity in cirrhotic rats.
- Sook In Chung, J. Seong, Y. N. Park, W. Kim, Haejin Oh, K. Han
- Medicine, BiologyJournal of radiation research
- 1 November 2010
60 proteins indicating radiation-induced hepatic toxicity in cirrhotic rats, which can be used as possible biomarkers, were identified and an increase of heparanase precursor and decrease of hepatocyte growth factor were shown commonly in liver tissue and serum following radiation.
Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1
- Jong Doo Lee, Min-Ah Choi, Jeon‐Han Park
- Medicine, BiologyEuropean journal of cancer prevention : the…
- 1 March 2015
An isocaloric carbohydrate-restriction diet and natural AMPK-activating agents induce synergistic anticancer effects and SIRT1 acts as a tumor suppressor under a low-glucose condition in the transgenic liver cancer model developed by hydrodynamic transfection.
Comparison of liver oncogenic potential among human RAS isoforms
No differences were found in the hepatocarcinogenic potential among RAS isoforms, as determined by both gross examination of livers and liver weight per body weight ratio (LW/BW), however, the tumorigenic potential differed significantly between KRAS splicing variants.
Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background
Considering the simplicity and efficiency in generating HCC for fibrotic livers, the transgenic HCC model has the potential to be effectively used in preclinical testing of HCC anticancer therapy and in studies of hepatocarcinogenesis in fibrotIC livers.
Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats
Co-incidental administration of LAB and nivocasan suppressed oxidative stress and apoptosis, resulting in enhanced reversal of hepatic fibrosis in rat.
Transgenic mouse model expressing P53R172H, luciferase, EGFP, and KRASG12D in a single open reading frame for live imaging of tumor
The transgenic mouse model, developed in which two oncogenes, encoding P53R172H and KRASG12D, are expressed together with two reporter genes, encoding enhanced green fluorescent protein (EGFP) and firefly luciferase, in a single open reading frame following Cre-mediated DNA excision, revealed a continuous increase in the bioluminescent signal over time.