Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Whether these mutations identify a clinical opportunity is an important question. Inhibition of Wnt secretion by blocking an essential post-translational modification, palmitoleation, provides a useful… (More)
A series of triorganophosphinegold(1) dithiocarbamate (R(3)PAuS(2)CNR'(2)) and xanthate (R(3)PAuS(2)COR') complexes have been prepared and characterised spectroscopically. Based on crystallographic evidence, the molecules feature linear gold(1) geometries defined by sulphur and phosphorus donors. The complexes, along with a series of known anti-cancer… (More)
Porcupine is a component of the Wnt pathway which regulates cell proliferation, migration, stem cell self-renewal, and differentiation. The Wnt pathway has been shown to be dysregulated in a variety of cancers. Porcupine is a membrane bound O-acyltransferase that palmitoylates Wnt. Inhibiting porcupine blocks the secretion of Wnt and effectively inhibits… (More)
The binuclear title compound, [Au(2)Fe(C(9)H(10)NOS)(2)(C(17)H(14)P)(2)]·CH(2)Cl(2), which has the Fe atom located on a crystallographic centre of inversion, crystallizes as a 1:1 dichloro-methane solvate, which is disordered about a centre of inversion. There is a small deviation from linearity defined by the SP donor set [S1-Au-P1 angle is 175.35 (5) °]… (More)
Each gold atom in the binuclear title compound, [Au(2)(C(9)H(9)N(2)O(3)S)(2)(C(25)H(22)P(2))], is coordinated within an S,P-donor set that defines a slightly distorted linear geometry [S-Au-P angles = 172.77 (6) and 173.84 (6)°], with the distortion due in part to a close intra-molecular Au⋯O contact [2.968 (11) and 2.963 (4) Å]. The mol-ecule adopts a… (More)
An S,P-donor set in the title solvate, [Au(C(9)H(9)N(2)O(3)S)(C(18)H(15)P)]·CH(2)Cl(2), defines a linear geometry for the Au(I) atom [S-Au-P = 177.75 (7)°], with the minor distortion ascribed to the influence of an intra-molecular Au⋯O contact [3.019 (6) Å]. In the crystal, the packing is stabilized by a network of C-H⋯S, C-H⋯N and C-H⋯O contacts.
In the title compound, [Au(C(9)H(9)N(2)O(3)S)(C(6)H(15)P)], two virtually identical mol-ecules comprise the asymmetric unit. These are connected by Au⋯Au [3.6796 (4) Å] and Au⋯S [3.6325 (18) and 3.5471 (18) Å] contacts, forming a dimeric aggregate. The presence of intra-molecular Au⋯O contacts [2.993 (5) and 2.957 (5) Å] is responsible for the slight… (More)
The dinuclear title mol-ecule, [Au(2)Fe(C(10)H(11)N(2)O(3)S)(2)(C(17)H(14)P)(2)]·2CHCl(3), has crystallographic twofold symmetry with the Fe atom (bonded to two η(5)-cyclo-penta-dienyl rings) situated on the rotation axis. The Au atom exists within a linear geometry defined by an S,P-donor set with a deviation from linearity [S-Au-P = 176.86 (6)°] due to… (More)