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Interleukin-32: a cytokine and inducer of TNFalpha.
Induced in human peripheral lymphocyte cells after mitogen stimulation, in human epithelial cells by IFNgamma, and in NK cells after exposure to the combination of IL-12 plus IL-18, IL-32 may play a role in inflammatory/autoimmune diseases. Expand
Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor.
This review focuses on the current understanding of integrins and heparan sulphate proteoglycans as the essential cellular machineries that sense, integrate and respond to the physical and chemical environmental information either by directly connecting with the local adhesion sites or by regulating global cellular processes through growth factor receptor signalling pathways, leading to the integration of both external and internal signals in space and time. Expand
Regulation of myeloid leukemia by the cell fate determinant Musashi
The data show that the Musashi–Numb pathway can control the differentiation of CML cells, and raise the possibility that targeting this pathway may provide a new strategy for the therapy of aggressive leukaemias. Expand
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
It is found that SAHA reduces the production of proinflammatory cytokines in vivo and in vitro and may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets. Expand
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
The modulation of intracellular NOD2 pathways by IL-32, but not cell-surface TLRs, and the marked expression ofIL-32 in colon mucosa suggest a role of IL- 32 in the pathogenesis of Crohn's disease. Expand
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
It is proposed that after binding to IL-18BP, IL-1F7b forms a complex with IL-16Rβ, depriving the β-chain of forming a functional receptor complex withIL-18Rα and thus inhibiting IL- 18 activity. Expand
Overview of interleukin‐18: more than an interferon‐γ inducing factor
Interleukin‐18 is a novel proinflammatory cytokine that is clearly more than an inducer of IFN‐γ and possesses several biological properties such as activation of nuclear factor‐κB, Fas ligand expression, the induction of both CC and CXC chemokines, and increased production of competent human immunodeficiency virus. Expand
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism
The results confirm the therapeutic potential of the compounds and suggest that the antimetastatic and anti‐tumor effects of CA and CAPE are mediated through the selective suppression of MMP‐9 enzyme activity and transcriptional down‐regulation by the dual inhibition of NF‐κB as well as M MP‐9 catalytic activity. Expand
IL-32, a proinflammatory cytokine in rheumatoid arthritis.
IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases. Expand
Antioxidant Potential of Ecklonia cavaon Reactive Oxygen Species Scavenging, Metal Chelating, Reducing Power and Lipid Peroxidation Inhibition
The antioxidative potential of different fractions (respective organic and aqueous fractions of n-hexane, chloroform and ethyl acetate) of 70% methanol extract of Ecklonia cava(a brown seaweed) wasExpand