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In Vivo Insulin Resistance Induced by Amylin Primarily Through Inhibition of Insulin-Stimulated Glycogen Synthesis in Skeletal Muscle
TLDR
The results suggest that amylin antagonizes the ability of insulin to promote total-body glucose uptake primarily by decreasing muscle glycogen synthesis, which, in turn, determines an increase in muscle glucose-6-phosphate levels and glycolysis and a reduction in glucose transport/phosphorylation.
Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized rats.
TLDR
The improvement of beta-cell function and survival via the activation of an insulin/IGF-I signaling cascade due to exercise has a crucial role in preventing the development and progression of type 2 diabetes.
Estrogen and exercise may enhance beta-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic rats.
The prevalence and progression of type 2 diabetes have increased remarkably in postmenopausal women. Although estrogen replacement and exercise have been studied for their effect in modulating
Improvement of Insulin Resistance and Insulin Secretion by Water Extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% Pancreatectomized Rats
TLDR
A water extract of C. militaris ameliorates insulin resistance by enhancing glucose utilization in skeletal muscles by enhancing insulin resistance in rats that consumed P. tenuipes in hyperglycemic clamp.
Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma.
TLDR
Data suggested that berberine can act as an effective insulin sensitizing and insulinotropic agent and can be used as anti-diabetic agent for obese diabetic patients.
Induction of long‐term normoglycemia without medication in Korean type 2 diabetes patients after continuous subcutaneous insulin infusion therapy
TLDR
The clinical characteristics that influenced the induction of remission were determined and it was determined that some Korean type 2 diabetic patients could maintain long‐term normal blood glucose control without any medication.
Effects of α-tocopherol supplementation and continuous subcutaneous insulin infusion on oxidative stress in Korean patients with type 2 diabetes
BACKGROUND Most Koreans with type 2 diabetes are insulin deficient and insulin resistant. Continuous subcutaneous insulin infusion (CSII) provides a suitable amount of insulin to overcome insulin
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