Sonya E Ensslen-Craig

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The regulation of tyrosine phosphorylation is recognized as an important developmental mechanism. Both addition and removal of phosphate moieties on tyrosine residues are tightly regulated during development. Originally, most attention focused on the role of tyrosine kinases during development, but more recently, the developmental importance of tyrosine(More)
Inhibition of protein-tyrosine phosphatases (PTPs) counterbalancing protein-tyrosine kinases (PTKs) offers a strategy for augmenting PTK actions. Conservation of PTP catalytic sites limits development of specific PTP inhibitors. A number of receptor PTPs, including the leukocyte common antigen-related (LAR) receptor and PTPmu, contain a wedge-shaped(More)
During development of the visual system, retinal ganglion cells (RGCs) require cell-cell adhesion molecules and extracellular matrix proteins for axon growth. In this study, we demonstrate that the classical cadherin, E-cadherin, is expressed in RGCs from E6 to E12 and promotes neurite outgrowth from all regions of the chick retina at E6, E8 and E10.(More)
Cell adhesion molecules (CAMs) regulate neural development via both homophilic and heterophilic binding interactions. Various members of the receptor protein tyrosine phosphatase (RPTP) subfamily of CAMs mediate neurite outgrowth, yet in many cases, their ligands remain unknown. However, the PTP mu subfamily members are homophilic binding proteins. PTP mu(More)
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