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Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. The universal outreach of cells in an injured state has myriad consequences to distant organ cells and their milieu. Heart(More)
Cardiorenal Syndrome Type 1 (Type 1) is a specific condition which is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Even though its pathophysiology is complex and not still completely understood, oxidative stress seems to play a pivotal role. In this study, we examined the putative role of oxidative stress in(More)
The purpose of this investigation was to study the possible mechanism of the potentiation of the contractile response and myotonia caused by Cd2+ in the mouse diaphragm. Cd2+ increased both amplitude and duration of the contractile response to direct stimulation in either 0.25 mM Ca2+ Krebs or 2.5 mM Ca2+ Krebs containing the K+-channel blockers,(More)
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