Sonja Visscher

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BACKGROUND Hereditary angioedema (HAE) results from a genetic deficiency of C1-inhibitor. Two similar independent, randomized, saline controlled, double-blind studies were conducted to evaluate the efficacy and safety of recombinant human C1-inhibitor (rhC1INH) as a treatment of acute angioedema attacks in patients with HAE. OBJECTIVE Analysis of pooled(More)
BACKGROUND Hereditary angioedema (HAE) owing to C1 inhibitor deficiency is an autosomal dominant disorder, characterized by recurrent, potentially life-threatening, localized attacks of tissue swelling. Current treatment involves the infusion of C1 inhibitor protein (C1-INH) isolated from human plasma. OBJECTIVES This open-label extension to a European,(More)
BACKGROUND Hereditary angioedema (HAE) is a disease characterized by recurrent tissue swelling affecting various body locations. Recent literature shows that patients with frequent attacks may benefit from long-term prophylaxis. This study evaluated the safety and prophylactic effect of weekly administrations of recombinant C1INH (rhC1INH). METHODS(More)
The development of optical techniques for non-invasive diagnosis of cancer is an ongoing challenge to biomedical optics. For oral cancer biopsy has a low specificity because of a thick keratin layer that often covers potential malignancies. We investigated the possibility to distinguishing potentially malignant visible lesions from benign ones to reduce the(More)
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