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Persistent contaminants in ecosystems are often monitored via organisms that bioaccumulate the pollutant of interest. Several published studies have used colonial wading birds to assess contamination by heavy metals in aquatic ecosystems. Using a nonlethal sampling regimen, this study identified chick feathers and guano as tissues that best reflect local(More)
Epidemiologic studies have suggested a positive association in man between nicotine use and the incidence of tardive dyskinesia, a disease characterized by dopaminergic supersensitivity after chronic neuroleptic therapy. In rats, repeated administration of neuroleptics results into dopaminergic supersensitivity and increased density of striatal D2-dopamine(More)
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common human inherited diseases. Modifier genes seem to modulate the disease progression and might therefore be promising drug targets. Although a number of modifier loci have been already identified, no modifier gene has been proven to be a real modifier yet. METHODS Gene(More)
Effect of chronic thyrotropin-releasing hormone (TRH) treatment on the properties of spinal cord TRH-receptor was evaluated by Scatchard analysis of data on the saturation of specific binding of [methyl-His3-3H]TRH. Continuous subcutaneous administration of TRH (0.51 +/- 0.02 mg/kg/day) via an Alzetmini osmotic pump for ten days led to a substantial(More)
An accelerated loss of dopaminergic neurons with advancing age leads to Parkinson's disease. The incidence of this disease is suggested to be lower in nicotine users. As the body ages, the number of dopamine receptors in the striatum decrease, an effect that has been shown to be slowed by reduction in body weight via dietary manipulations. To investigate(More)
Many biologic effects of TRH seem to be mediated via a dopaminergic mechanism. The present study examined the effects of chronic TRH administration on the properties of nigrostriatal dopaminergic neurons. Ten days, continuous subcutaneous TRH administration via an osmotic minipump led to a significant rise in striatal level of 3,4-dihydroxyphenylacetic(More)
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