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Structural basis of multivalent binding to wheat germ agglutinin.
- D. Schwefel, Caroline Maierhofer, +5 authors V. Wittmann
- Chemistry, Medicine
- Journal of the American Chemical Society
- 30 June 2010
The findings show that bridging adjacent protein binding sites by multivalent ligands is a valid strategy to find high-affinity protein ligands and that even subtle changes of the linker structure can have a significant impact on the binding affinity. Expand
A New Strategy for the Synthesis of Taurine Derivatives Using the “Safety‐Catch” Principle for the Protection of Sulfonic Acids.
Spatial screening of cyclic neoglycopeptides: identification of polyvalent wheat-germ agglutinin ligands.
Solid-phase peptide synthesis was carried out in plastic syringe reactors and compound numbers used within this supporting information are the same as in the printed article. Expand
Combinatorial Solid-Phase Synthesis of Multivalent Cyclic Neoglycopeptides.
After treatment of a resin sample with the cleavage cocktail, remaining 8 was extracted with MeOH from the solid support with retention time tR = 18.5 min; ESI-MS (M + H ): calcd.6. Expand
A new strategy for the synthesis of taurine derivatives using the 'safety-catch' principle for the protection of sulfonic acids.
- Sonja Seeberger, R. Griffin, I. Hardcastle, B. Golding
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 7 January 2007
The safety-catch principle has been applied for the development of a new method for protecting sulfonic acids and should be generally applicable to the protection of sulfonic acid and is amenable to a multiparallel format. Expand
Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides
Abstract Employing a cleavable carbohydrate–peptide linker, a new strategy for single-bead analysis of multivalent cyclic neoglycopeptides based on Edman degradation is described. Edman degradation… Expand
Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach
Carbohydrate–lectin interactions mediate a large variety of intercellular recognition events. Since the interactions of individual saccharide groups are usually of low affinity and broad specificity,… Expand
Spatial Screening of Lectin Ligands : Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates
Carbohydrate-lectin interactions are the basis of numerous biologically important recognition processes . Examples include the initiation of the inflammatory response, bacterial and viral… Expand
Crystal Structure of Wheat Germ Agglutinin Isolectin 1 in Complex with Glycosylurethan