Sonja Hetzer

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BACKGROUND In recent years inhibitors directed against the epidermal growth factor receptor (EGFR) have evolved as effective targeting cancer drugs. Characteristic papulopustular exanthemas, often described as acneiform rashes, are the most frequent adverse effect associated with this class of novel cancer drugs and develop in > 90% of patients. Notably,(More)
BACKGROUND Bosentan is a dual endothelin receptor antagonist initially introduced for the treatment of pulmonary arterial hypertension and recently approved for the treatment of digital ulcers in patients with systemic sclerosis (SSc). Our clinical observations indicate that bosentan therapy may be associated with an increased frequency of centrofacial(More)
Anetodermie ist eine seltene Erkrankung, bei der es durch Verlust elastischer Fasern zum Auftreten scharf begrenzter, erythematöser, atropher, hernienartiger Plaques bevorzugt am Stamm und den proximalen Extremitäten kommt. Die Ursache ist unbekannt. Eine Assoziation mit Autoimmunerkrankungen sowie Infektionen, insbesondere Spirochäteninfektionen, wird(More)
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