Sonja G. Prager

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IMPORTANCE Biomarkers that predict future visual acuity (VA) in eyes with baseline diabetic macular edema (DME) would substantively improve risk assessment, management decisions, and selection of eyes for clinical studies targeting DME. OBJECTIVE To determine whether baseline or early change in the novel spectral domain-optical coherence tomography(More)
PURPOSE To image the ultrastructural morphology of retinal laser effects and their healing response in vivo using spectral domain optical coherence tomography (SD-OCT). DESIGN Prospective, interventional study. PARTICIPANTS Ten patients undergoing panretinal photocoagulation for proliferative diabetic retinopathy. METHODS Panretinal photocoagulation(More)
PURPOSE To study the changes in the distribution and morphologic features of intraretinal microexudates after macular photocoagulation. DESIGN Prospective cohort study. PARTICIPANTS Thirteen treatment-naïve patients with clinically significant macular edema in type 2 diabetes. METHODS Patients were treated with focal macular photocoagulation. Changes(More)
Despite treatment advances, diabetic eye disease remains a leading cause of visual acuity (VA) loss worldwide. No methods to prospectively determine which patients will gain or lose vision exist, limiting individualized risk assessment and management. We investigated whether noninvasive, readily obtainable spectral domain optical coherence tomography(More)
PURPOSE The aim of this study was to correlate different types of retinal morphologic alterations secondary to diabetic macular disease with their characteristic impact on retinal function. METHODS In the present cross-sectional study, 26 eyes of 26 diabetic patients with clinically significant macular edema were examined. All patients underwent complete(More)
Purpose To determine whether cone density, spacing, or regularity in eyes with and without diabetes (DM) as assessed by high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) correlates with presence of diabetes, diabetic retinopathy (DR) severity, or presence of diabetic macular edema (DME). Methods Participants with type 1 or 2 DM and(More)
PURPOSE To determine precisely the mean change in refractive power induced by treatment in patients with diabetic macular edema (DME). DESIGN Prospective, randomized study. PARTICIPANTS Fifty eyes of 50 consecutive patients with clinically significant macular edema receiving all 3 types of current state-of-the-art treatment with intravitreal(More)
The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below(More)
PURPOSE To evaluate changes in the distribution and morphology of intraretinal microexudates and hard exudates (HEs) during intravitreal anti-vascular endothelial growth factor therapy in patients with persistent diabetic macular edema. METHODS Twenty-four patients with persistent diabetic macular edema after photocoagulation were investigated in this(More)
We present a new compact multi-modal imaging prototype that combines an adaptive optics (AO) fundus camera with AO-optical coherence tomography (OCT) in a single instrument. The prototype allows acquiring AO fundus images with a field of view of 4°x4° and with a frame rate of 10fps. The exposure time of a single image is 10 ms. The short exposure time(More)