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Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.
The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of tissues for which cells originate far from their final destination. Carcinoma cells hijack this program forExpand
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Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets.
Protease inhibitors are key components in the chemotherapy of HIV-1 infection. However, the long term efficacy of antiretroviral therapies is hampered by issues of patient compliance often associatedExpand
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Structural and thermodynamic basis of resistance to HIV-1 protease inhibition: implications for inhibitor design.
One of the most serious side effects associated with the therapy of HIV-1 infection is the appearance of viral strains that exhibit resistance to protease inhibitors. At the molecular level,Expand
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A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV‐1 protease
The efficacy of HIV‐1 protease inhibition therapies is often compromised by the appearance of mutations in the protease molecule that lower the binding affinity of inhibitors while maintaining viableExpand
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