Sonia Traverso

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Opening of CLC chloride channels is coupled to the translocation of the permeant anion. From the recent structure determination of bacterial CLC proteins in the closed and open configuration, a glutamate residue was hypothesized to form part of the Cl--sensitive gate. The negatively charged side-chain of the glutamate was suggested to occlude the permeation(More)
The pathways of lead (Pb(2+)) uptake were studied in fura-2-loaded cerebellar granule cells from 8-day-old rats. In a nominal Ca-free external bath, Pb(2+) (5-50 microM) determined an increase of the fluorescence emission ratio (R = E(340)/E(380)) even in the absence of any specific stimulus. This rise was dose-dependent, was not significantly affected by(More)
CLC Cl- channels are homodimers in which each subunit has a proper pore and a (fast) gate. An additional slow gate acts on both pores. A conserved glutamate (E166 in CLC-0) is a major determinant of gating in CLC-0 and is crucially involved in Cl-/H+ antiport of CLC-ec1, a CLC of known structure. We constructed tandem dimers with one wild-type (WT) and one(More)
CLC proteins are a nine-member gene family of Cl- channels that have diverse roles in the plasma membrane and in intracellular organelles. The recent structure determination of bacterial CLC homologues by Dutzler et al. was a breakthrough for the structure-function analysis of CLC channels. This review describes the mechanisms of inhibition of muscle type(More)
  • Ionut Trestian, bullet Advisor, Aleksandar Kuzmanovic, O Cret, I Trestian, F De Dinechin +9 others
  • 2012
Contact Information Analyzing the social behavior (application activity patterns, mobility patterns) of In-Research Interests ternet users and designing and analyzing systems that take such behavior into account for scaling and usability purposes Conferences " TailGate: Handling long-tail content with a little help from friends " .
  • L Abeni, C Kiraly, R Birke, M Mellia, E Leonardi, S Traverso +1 other
  • 2010
I. DESCRIPTION OF THE DEMO This demonstration will present a tool that allows the evaluation of the impact of P2P distribution on video quality, as a function of various parameters and design choices of the streaming system, such as: • media-aware chunkisation with and without substreaming vs. non-media-aware chunkisation; • different chunk trading(More)
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