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Biological agents, particularly anti-Tumour Necrosis Factor (TNF)-α agents, have emerged as an effective treatment in patients with chronic inflammatory diseases. An association between anti-TNF-α antibodies and reactivation of latent tuberculosis infection (LTBI) has been established. Appropriate screening for TB infection has become mandatory before(More)
OBJECTIVE To analyze the clinical and laboratory characteristics and outcomes of patients with transverse myelitis affecting more than 4 spinal segments secondary to systemic lupus erythematosus (SLE). METHODS A computer-assisted (PubMed) search of the literature was performed to identify all cases of transverse myelitis affecting more than 4 spinal(More)
OBJECTIVE To assess the possible therapeutic effect of 40 mg sublingual piroxicam (fast-dissolving dosage form, FDDF) compared with intramuscular 75 mg diclofenac, as a reference drug, on acute renal colic in a randomized, double-blind controlled clinical trial. PATIENTS AND METHODS Eighty patients were assigned to one of two treatment groups; one(More)
BACKGROUND Visceral leishmaniasis is a protozoan infection usually asymptomatic, but can progress to fatal disease in immunocompromised hosts, especially in HIV patients. Visceral leishmaniasis is rare among patients under immunosuppressive therapies, and even more among patients under anti-TNF-alpha treatment, where only four cases have been described. (More)
We appreciate the comments from Dr. Wang and colleagues on our article (CHEST 1995; 108:670-76) based on their experi¬ ence with a case of unilateral pulmonary artery agenesis (UPAA) in an adult. Our statement that "many patients with UPAA had a benign clinical course" does not conflict with their observations. It is well known that patients with UPAA may(More)
BACKGROUND Densitometric screening for osteoporosis in postmenopausal women has not been demonstrated cost-effective. We have tried to identify clinical factors for screening previous to densitometry avoiding unnecessary explorations. PATIENTS AND METHODS SETTING outpatient clinics of a menopausal unit in a 450-bed general hospital. Cross-sectional(More)