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Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of(More)
We present a new model-based test case generation approach, which takes inputs an executable system model and preliminary test case coverage, performs an automated model simulation, and eventually generates refined test cases for software testing. We adopt Live Sequence Charts to specify an executable system model, and present a logic-based model simulator(More)
Rheumatoid arthritis is a chronic degenerative autoimmune disease characterized by persistent inflammation of synovial membranes, which leads to cartilage destruction and bone erosion. To date, there are no effective therapies to slow the progress of this degenerative condition. Here, we evaluate the anti-arthritic effect of chebulanin, an abundant(More)
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