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This paper presents an improved quantum-behaved particle swarm optimization (IQPSO) for short-term combined economic emission hydrothermal scheduling, which is formulated as a bi-objective problem: (i) minimizing fuel cost and (ii) minimizing emission cost. In this paper, quantum-behaved particle swarm optimization is improved employing heuristic strategies(More)
N-Acyl-2-aminothiazoles with nonaromatic acyl side chains containing a basic amine were found to be potent, selective inhibitors of CDK2/cycE which exhibit antitumor activity in mice. In particular, compound 21 [N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide, BMS-387032], has been identified as an ATP-competitive(More)
High throughput screening identified 2-acetamido-thiazolylthio acetic ester 1 as an inhibitor of cyclin-dependent kinase 2 (CDK2). Because this compound is inactive in cells and unstable in plasma, we have stabilized it to metabolic hydrolysis by replacing the ester moiety with a 5-ethyl-substituted oxazole as in compound 14. Combinatorial and parallel(More)
Short-term combined economic emission hydrothermal scheduling (CEES) is a bi-objective problem: (i) minimizing fuel cost and (ii) minimizing pollutant emission. In this paper, quadratic approximation based differential evolution with valuable trade off approach (QADEVT) has been developed to solve the bi-objective hydrothermal scheduling problem. The(More)
Synthesis and SAR of substituted pyrrolotriazine-4-one analogues as Eg5 inhibitors are described. Many of these analogues displayed potent inhibitory activities in the Eg5 ATPase and A2780 cell proliferation assays. In addition, pyrrolotriazine-4-one analogue 26 demonstrated in vivo efficacy in an iv P388 murine leukemia model. Both NMR and X-ray(More)
N-Aryl aminothiazoles 6-9 were prepared from 2-bromothiazole 5 and found to be CDK inhibitors. In cells they act as potent cytotoxic agents. Selectivity for CDK1, CDK2, and CDK4 was dependent of the nature of the N-aryl group and distinct from the CDK2 selective N-acyl analogues. The N-2-pyridyl analogues 7 and 19 showed pan CDK inhibitory activity.(More)
In this paper we describe a new approach to distinguish and extract text from images with various objects and complex backgrounds. The goal of our approach is to present characters in images with clear background and without other objects. The proposed approach mainly includes two steps. Firstly, a densitybased clustering method is employed to segment(More)
Eg5 is a kinesin whose inhibition leads to cycle arrest during mitosis, making it a potential therapeutic target in cancers. Circular dichroism and isothermal titration calorimetry of our pyrrolotriazine-4-one series of inhibitors with Eg5 motor domain revealed enhanced binding in the presence of adenosine 5'-diphosphate (ADP). Using this information, we(More)