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Synapsin I is a synaptic vesicle-associated protein, participating in synapse formation, regulation of the synthesis of other synaptic vesicle proteins and promotion of neurotransmitter release. The aim of present study was to detect whether regional alteration of synapsin I occurred in the hippocampal formation of Alzheimer's disease (AD) patients. Samples(More)
To investigate olfactory identification and apolipoprotein E epsilon 4 allele in patients with mild cognitive impairment (MCI), we used Cross-Cultural Smell Identification Test (CC-SIT) from University of Pennsylvania to assess olfactory identification performance and polymerase chain reaction (PCR) to detect apolipoprotein E epsilon 4 (ApoE epsilon 4)(More)
Given an array with n elements, we want to rearrange them in ascending order. Sorting algorithms such as the Bubble, Insertion and Selection Sort all have a quadratic time complexity that limits their use when the number of elements is very big. In this paper, we introduce Merge Sort, a divide-and-conquer algorithm to sort an N element array. We evaluate(More)
Microglia are highly motile cells that act as the main form of active immune defense in the central nervous system. Attracted by factors released from damaged cells, microglia are recruited towards the damaged or infected site, where they are involved in degenerative and regenerative responses and phagocytotic clearance of cell debris. ATP release from(More)
Neural stem cells (NSCs) are self-renewing multipotent progenitors that generate both neurons and glia. The precise control of NSC behavior is fundamental to the architecture and function of the central nervous system. We previously demonstrated that the orphan nuclear receptor TLX is required for postnatal NSC activation and neurogenesis in the neurogenic(More)
Transcription factors play key roles in the formation of a multilayered cerebral cortex consisting of neurons and glial cells. Krüppel-like factor 4 (KLF4) is expressed in neural stem cells and controls axonal regeneration. Its dysregulation leads to hydrocephalus in postnatal mouse brains. Here, we further show that KLF4 regulates neurogenesis and radial(More)
p75(NTR), a low-affinity neurotrophin receptor, may be involved in the pathogenesis of Alzheimer's disease (AD). The aim of present study was to detect the relationship between p75(NTR)-containing neurons and the pretangles consisting of hyperphosphorylated tau stained by Alz-50 in the hippocampus of AD patients. Samples of hippocampus of 10 female AD(More)
The age-related decline of learning and memory is a common phenomenon in humans and animals, even though the underlying mechanism is not yet known. In the present study, we propose that synaptotagmin 1 (Syt 1) might be a synaptic protein involved in the loss of learning and memory with aging. To test this hypothesis, the age-related spatial cognitive(More)
Emerging evidence has demonstrated the neuroprotection of estrogen in Alzheimer's disease (AD). The hippocampus, an important target of estrogen action, is severely affected in the Alzheimer process. The aim of present study was to detect the distribution of estrogen receptor-alpha (ER-alpha) and the relationship between ER-alpha-containing neurons and the(More)
BACKGROUND Cyanobacteria are an ancient group of photoautotrophic prokaryotes with wide variations in genome size and ecological habitat. Metacaspases (MCAs) are cysteine proteinases that have sequence homology to caspases and play essential roles in programmed cell death (PCD). MCAs have been identified in several prokaryotes, fungi and plants; however,(More)