Song-Ming Chen

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BACKGROUND Heme oxygenase (HO) is a rate-limiting enzyme of endogenetic carbon monoxide (CO) that degrades heme into carbon monoxide, bilirubin, and iron. These products have important physiologic effects: bilirubin is a potent antioxidant that can act against ischemia/reperfusion injury; there is a negative correlation between the content of HO-1 and the(More)
BACKGROUND The increased expression of heme oxygenase-1 content, a stress-response protein, directly correlates with the incidence of coronary heart disease. Down-regulation of hypoxia inducible factor-1alpha activity, a major downstream effector of the signaling pathways activated by hypoxia, increases cell survival after hypoxia. The ubiquitin system, a(More)
BACKGROUND Marked variability exists in coronary artery collaterals in patients with ischemic heart disease. Multiple factors are thought to play a role in collateral development; however, the contribution of hypoxia inducible factor-1alpha (HIF-1alpha), which is a transcriptional activator that functions as a master regulator of oxygen homeostasis, is not(More)
OBJECTIVE The aim of this paper was to investigate the association between levels of HO-1 expression and angiographic morphology as well as the quantity of coronary lesions in patients with coronary heart disease (CHD). METHODS 110 patients with CHD were diagnosed by coronary angiography which contained coronary lesions in some way. Firstly, the patients(More)
AIMS This study aimed to investigate the association of Hypoxia-inducible factor-1α (HIF-1α) C1772T and G1790A single nucleotide polymorphisms (SNPs) with: incidence, clinical type, severity of coronary atherosclerosis and coronary collaterals of coronary artery disease (CAD). METHODS The clinical data and genomic DNA were gathered in 958 subjects,(More)
OBJECTIVE To investigate changes in heme oxygenase-1(HO-1) in patients with acute myocardial infarction. METHODS Forty-five patients with acute myocardial infarction and 50 with coronary heart disease (diagnosed by coronary angiography) but without acute myocardial infarction were included in this study, and another 40 patients with normal coronary artery(More)
Aims. This study aimed to investigate the association of Hypoxia-inducible factor-1α (HIF-1α) C1772T and G1790A single nucleotide polymorphisms (SNPs) with: incidence, clinical type, severity of coronary atherosclerosis and coronary collaterals of coronary artery disease (CAD). Methods. The clinical data and genomic DNA were gathered in 958 subjects,(More)
Dear Editor, Sleep-disordered breathing (SDB) is associated with increased risk of adverse cardiovascular events and mortality [1]. Atrial fibrillation (AF) is a huge health care problem, remaining one of the major causes of stroke, heart failure, and cardiovascular morbidity. SDB is an independent risk factor for AF. However, little is known about the(More)
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