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Understanding the Molecular Mechanisms of the Interplay Between Herbal Medicines and Gut Microbiota
More advanced experimental designs are recommended for future study, such as overall chemical characterization of gut microbiota‐metabolized HMs, direct microbial analysis of HM‐targeted gut microbiota, and precise gut microbiota research model development, to further elucidate the interactions between HMs and gut microbiota.
Discrimination of leaves of Panax ginseng and P. quinquefolius by ultra high performance liquid chromatography quadrupole/time-of-flight mass spectrometry based metabolomics approach.
The results suggested that UHPLC-QTOF-MS/MS based metabolomics approach is a powerful tool to rapidly find characteristic markers for the quality control of LPG.
Chemistry, bioactivity and quality control of Dendrobium, a commonly used tonic herb in traditional Chinese medicine
The fresh or dried stems of many Dendrobium species are well known as one of the most expensive tonics in traditional Chinese medicine. Documented as a “superior grade” herbal medicine in the ancient
Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction
Results indicated that ginseng polysaccharides improved intestinal metabolism and absorption of certain ginsenosides, meanwhile reinstated the perturbed holistic gut microbiota, and particularly enhanced the growth of Lactobacillus spp.
Quantitative evaluation of Radix Paeoniae Alba sulfur-fumigated with different durations and purchased from herbal markets: simultaneous determination of twelve components belonging to three chemical
Improved high performance liquid chromatography-diode array detector (HPLC-DAD) method was applied to quantitatively compare the quality of Radix Paeoniae Alba (RPA) sulfur-fumigated with different durations and purchased from commercial herbal markets, suggesting that the established method was precise, accurate and sensitive enough for the global quality evaluation of sulfur- fumigated RPA.
Detection of Sulfur-Fumigated Paeoniae Alba Radix in Complex Preparations by High Performance Liquid Chromatography Tandem Mass Spectrometry
Paeon iflorin and paeoniflorin sulfonate could be simultaneously detected in different commercial PAR-containing complex preparations without interference of other components using the established method, indicating that the newly established method was selective and sensitive enough for screening sulfur-fumigated PAR in commercial complex preparations.
Simultaneous determination of iridoid glycosides, phenethylalcohol glycosides and furfural derivatives in Rehmanniae Radix by high performance liquid chromatography coupled with triple-quadrupole
In this study, a sensitive and selective method for simultaneously quantifying eight major components of Rehmanniae Radix by high performance liquid chromatography coupled with triple-quadrupole mass spectrometry (HPLC-TQ-MS) was developed and validated in terms of linearity, sensitivity, precision, accuracy and stability.
Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea
The four flavonoids in M. atropurpurea leaves could inhibit α-glucosidase activity and an analytical method for quantification of the compounds was developed.
Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid
It was found that ginseng could ameliorateCP-induced elevations of ALP, ALT, ALS, MDA and hepatic deterioration, enhance antioxidant enzymes’ activities and GSH’s level, and alleviate CP-induced hepatotoxicity via modulating the disordered homeostasis of GSH and bile acid.
Effects of sulfur-fumigation on the pharmacokinetics, metabolites and analgesic activity of Radix Paeoniae Alba.
Sulfur-fumigation altered the pharmacokinetics, as well as reduced the safety and efficacy of BS, suggesting that sulfur- fumigation is not recommended for post-harvest handling of BS.