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BACKGROUND Microarrays revolutionized biological research by enabling gene expression comparisons on a transcriptome-wide scale. Microarrays, however, do not estimate absolute expression level accurately. At present, high throughput sequencing is emerging as an alternative methodology for transcriptome studies. Although free of many limitations imposed by(More)
In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution, developmental retardation, or neoteny, has been proposed as a possible mechanism that contributed to the rise of many human-specific features, including an increase in brain size and the emergence of(More)
Among other factors, changes in gene expression on the human evolutionary lineage have been suggested to play an important role in the establishment of human-specific phenotypes. However, the molecular mechanisms underlying these expression changes are largely unknown. Here, we have explored the role of microRNA (miRNA) in the regulation of gene expression(More)
—Cloud is becoming a dominant computing platform. Naturally, a question that arises is whether we can beat notorious DDoS attacks in a cloud environment. Researchers have demonstrated that the essential issue of DDoS attack and defense is resource competition between defenders and attackers. A cloud usually possesses profound resources and has full control(More)
Hadoop is one popular implementation of MapReduce programming model, which has made programming on distributed system with much ease. In computer world, the convenience is always at the cost of performance. Comparing with MPI, Hadoop simplifies the programming, but it degrades the performance. In this work, we focus on the comparison between Hadoop and(More)
—A Genetic Algorithm (GA) is a heuristic to find exact or approximate solutions to optimization and search problems within an acceptable time. We discuss GAs from an architectural perspective, offering a general analysis of GAs on multi-core CPUs and on GPUs, with solution quality considered. We describe widely-used parallel GA schemes based on(More)
Wireless sensor networks (WSNs) are an emerging technology for monitoring physical world. Different from the traditional wireless networks and ad hoc networks, the energy constraint of WSNs makes energy saving become the most important goal of various routing algorithms. For this purpose, a cluster based routing algorithm LEACH (low energy adaptive(More)