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AIMS To determine the roles of vitamin D receptor (VDR) in ischemia/reperfusion-induced myocardial injury and to investigate the underlying mechanisms involved. RESULTS The endogenous VDR expression was detected in the mouse heart, and myocardial ischemia/reperfusion (MI/R) upregulated VDR expression. Activation of VDR by natural and synthetic agonists(More)
We propose a binary decision fusion rule that reaches a global decision on the presence of a target by integrating local decisions made by multiple sensors. Without requiring a priori probability of target presence, the fusion threshold bounds derived using Chebyshev's inequality ensure a higher hit rate and lower false alarm rate compared to the weighted(More)
A control-plane architecture for supporting advance reservation of dedicated bandwidth channels on a switched network infrastructure is described including the front-end web interface, user and token management scheme, bandwidth scheduler, and signaling daemon. A path computation algorithm for bandwidth scheduling is proposed based on an extension of(More)
“Cloud-based” Internet services rely on the availability and reliability of managed data centers. Recent events indicate that data centers tend to create centralized points of failure, and providing resilience to large-scale faults remains a significant challenge for both providers and users of cloud infrastructures. Running data centers also incurs high(More)
Although there exists many Semantic Web tools and APIs to help building semantic web applications, Java EE 3-tier architecture has been largely used in developing large enterprise applications. It is proved to be competent. Based on this architecture, we propose a layered architecture which is fit for developing semantic web applications. We discuss what(More)
UNLABELLED Animal studies have reported a cardioprotective effect for atrial natriuretic peptide (ANP) or brain natriuretic peptide (BNP) administration in the setting of acute myocardial infarction (AMI). However, previous trials performed on AMI patients have reported differences in the cardiac function protection for ANP/BNP infusion, making it diffi(More)
Positive evidence from clinical trials has fueled growing acceptance of traditional Chinese medicine (TCM) for the treatment of cardiac diseases; however, little is known about the underlying mechanisms. Here, we investigated the nature and underlying mechanisms of the effects of YiXin-Shu (YXS), an antioxidant-enriched TCM formula, on myocardial(More)
OBJECTIVES We sought to develop a new quantitative method to evaluate the degree of myocardial perfusion. BACKGROUND Currently available methods for assessing myocardial perfusion, both TIMI myocardial perfusion grading (TMPG) and myocardial blush grading (MBG), are subjective. METHODS TIMI Myocardial Perfusion Frame Count (TMPFC), an objective method(More)
BACKGROUND Myocardial tissue-level perfusion failure is associated with adverse outcomes following ST-elevation myocardial infarction (STEMI) despite successful epicardial recanalization. We have developed a new quantitative index-thrombolysis in myocardial infarction (TIMI) myocardial perfusion frame count (TMPFC)--for assessing myocardial tissue level(More)
OBJECTIVE The impact of gender on clinical course after ST-elevation myocardial infarction (STEMI) is not fully understood. We prospectively investigated whether there are gender-related differences in epicardial and myocardial tissue-level perfusion, both of which represent important prognostic determinants in STEMI patients undergoing primary percutaneous(More)