Sonal Goswami

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Post-traumatic stress disorder (PTSD) is a debilitating condition that develops in a proportion of individuals following a traumatic event. Despite recent advances, ethical limitations associated with human research impede progress in understanding PTSD. Fortunately, much effort has focused on developing animal models to help study the pathophysiology of(More)
Recent findings implicate the central lateral amygdala (CeL) in conditioned fear. Indeed, CeL contains neurons exhibiting positive (CeL-On) or negative (CeL-Off) responses to fear-inducing conditioned stimuli (CSs). In mice, these cells differ in their expression of protein kinase Cδ (PKCδ) and physiological properties. CeL-Off cells are PKCδ(+) and late(More)
Despite recent progress, the causes and pathophysiology of post-traumatic stress disorder (PTSD) remain poorly understood, partly because of ethical limitations inherent to human studies. One approach to circumvent this obstacle is to study PTSD in a valid animal model of the human syndrome. In one such model, extreme and long-lasting behavioral(More)
Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome. Lewis rats(More)
1 2 3 4 MORPHOLOGY, PKCδ EXPRESSION, AND SYNAPTIC RESPONSIVENESS OF 5 DIFFERENT TYPES OF RAT CENTRAL LATERAL AMYGDALA NEURONS 6 7 8 9 10 Taiju Amano, Alon Amir, Sonal Goswami, Denis Pare 11 12 Center for Molecular and Behavioral Neuroscience, Rutgers, 13 The State University of New Jersey, Newark, New Jersey 07102. 14 15 16 17 Running Head: Heterogeneity(More)
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